Bioconjugates synthesise and synergise the effects of biological entities, such as proteins, nucleic acids, or carbohydrates. They are often used in the development of new drugs and therapies because they offer a number of advantages over traditional drugs, such as improved targeting, increased potency, and reduced toxicity. Bioconjugates includes Antibody Drug Conjugates (ADCs), oligo-drug conjugates and antibody pairs.
In the realm of biotherapetics, bioconjugates emerge as a formidable challenge, as they encompass the analysis of multiple targets, each with potential interactions and interdependencies. Navigating the landscape of bioconjugate development demands profound comprehension of the involved molecules, their intricate biological pathways, precise concentrations, and crucial pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) properties. Meeting this challenge requires the development of assays capable of accurately measuring concentrations and stability, a task further complicated by the diverse mechanisms of action exhibited by bioconjugates and the diverse range of biological matrices they may affect.
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