In this AAPS eChalk Talk, our speakers will explore how Ion Mobility Spectrometry (IMS) is revolutionizing mass spectrometry by enhancing sensitivity and selectivity. They will discuss the advances in mass spectrometry and increase in throughput speed, specifically as it pertains to early-stage characterization in proteomics. Our experts will highlight how IMS introduces an additional dimension of separation, allowing for more robust isomer differentiation and post-translational modifications analysis. They will also cover practical applications in protein mapping, peptide sequencing, and the analysis of complex biomolecules such as proteins. This session will provide valuable insights for professionals in the pharmaceutical and biotechnology sectors looking to characterize target therapeutics with cutting-edge technology. – Understanding Ion Mobility Spectrometry (IMS) – Challenges Associated with Isomer Differentiation and PTM Identification -Applications Beyond Protein Therapeutics