In the realm of biotherapetics, bioconjugates emerge as a formidable challenge, as they encompass the analysis of multiple targets, each with potential interactions and interdependencies. Navigating the landscape of bioconjugate development demands profound comprehension of the involved molecules, their intricate biological pathways, precise concentrations, and crucial pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) properties. Meeting this challenge requires the development of assays capable of accurately measuring concentrations and stability, a task further complicated by the diverse mechanisms of action exhibited by bioconjugates and the diverse range of biological matrices they may affect.