DMPK is a core discipline that seeks to understand biotransformation and behavior of drug compounds in the body. Careful selection of appropriate assays is crucial to ensure an accurate reflection of these aspects both in vitro and in examining the time course and fate of drugs in vivo. These studies provide essential information on the absorption, distribution, metabolism, and excretion (ADME) of drugs in animals and humans, enabling informed decisions on drug development and dosage selection. With Sannova, trust your DMPK analyses to capable hands. We offer in vitro assays for understanding compound efficacy and safety, providing reliable results in handling complex biological matrices. Our lab features state-of-the-art instruments, including Sciex LC/MS/MS, Shimadzu HPLCs, Thermo Exploris Orbitrap HRMS, Agilent HPLC, Waters Infinity H UPLC, Agilent ICP/MS, and Milestone Ultrawave Digestion system, ensuring high accuracy and efficiency in DMPK studies. Experience our commitment to quality, speed, and flexibility as your CRO partner.
TK studies play a vital role in ethical drug development, serving as an essential component of ADME and PK studies. These studies analyze xenobiotic disposition, providing insights into drug behavior, exposure, and expected API behavior in biological matrices. As a boutique CRO, Sannova offers analytical support for feasibility, iterative testing, and drug safety studies. Our primary objective is to help you achieve an optimal balance between safety and efficacy in first-in-human studies by supporting TK, ADME and PK studies.
Sannova’s boutique bioanalytical CRO services are specifically tailored to provide exceptional support for kinetic studies in drug development. Our skilled team of scientists utilizes advanced analytical methods to accurately measure drug concentrations and characterize kinetic profiles. By conducting detailed ADME assessments, we assist clients in understanding crucial parameters such as drug clearance, half-life, and bioavailability. Streamline your drug development processes, and drive informed decisions for successful outcomes.
In vitro DMPK analyses require in-depth expertise and specific methodology order to fully elucidate the safety profile of your compound candidate. Simulation of complex matrices,including simulated gastric fluids in the presence of foods, aqueous humor, and various biological and synthetic surrogate membranes, is a specialized area of research.
Choose Sannova for exceptional quality, personalized services and excellent results, all delivered as quickly as our commitment to excellence allows.